Objective: To explore the relationship between the mean platelet volume (MPV) and varicocele to clarify the etiopathogenesis of varicocele. Methods: MPV levels were measured in 50 varicocele subjects (group I) and 46 healthy controls (group II). The results of the two groups were compared and analyzed. Results: The average patient age at the time of examination was23.50±5.08 years in group I and 24.67±4.33 in group II （P=0.599）. MPV levels were statistically significantly higher in group I than in group II （P=0.030）. Positive correlations were found between MPV and varicocele grade (P=0.03, r=0.497). Conclusions: The levels of MPV were higher in varicocele patients than in healthy peole. The increase in varicocele grade is associated with higher MPV in varicocele patients. The results can provide the reference for examining the etiopathogenesis of varicocele.