Objective Most of intracranial aneurysm models were small animals, which were not conducive to study on hemodynamics and endovascular therapy. This study induced the aneurysm formation at the basilar terminus by ligation of the bilateral common carotid artery of the New Zealand white rabbit. Methods Twenty six adult New Zealand white rabbits were subjected to sham, or bilateral common carotid artery ligation to produce basilar artery flow increase. Basilar artery flow velocity was monitored by transcranial Doppler, before the operation, and 1d, 1w, 4 weeks after surgery. Cerebral angiography was performed 4 weeks after surgery. The basilar arterys were seperated and compared morpholodical changes. Bifurcation tissues were harvested at 4 weeks and examined histologically. Results All animals survived in the sham group, and 80% ( 16 /20 ) survived in the experimental group. Subsequent to bilateral common carotid artery ligation, basilar artery flow velocity increased straightly, by 231% compared with the preoperation. The flow velocity kept on increasing 1 w after the operation and it was in a stable state after 4 weeks. The basal arteries augmented obviously and displayed tortuous in the experimental group. But there was no such change in the sham. All common carotid artery-ligated rabbits presented with thinned media and absent，rupture or thinned internal elastic lamina near the basilar terminus. Conclusion After the ligation of the bilateral common carotid arteries of New Zealand white rabbit, flow increase at the basilar bifurcation can lead to a change of the basilar artery morpholog and induced a nascent aneurysm in the basilar terminus.