Objective To evaluate the pharmacokinetics of curcumin phospholipid complex (CCPC) in rats following oral administration. Methods Blood samples were collected from the retinal venous plexus of SD rats after oral administration of CCPC or curcumin (CC), and the blood concentration of curcumin was determined by high-performance liquid chromatography (HPLC). Results The solubility and cumulative dissolution of CCPC (0.150 g/L and 68.04%, respectively) were higher than those of CC (0.057 g/L and 50.68%, respectively). The pharmacokinetic parameter of CCPC and CC were calculated as follows: C_max (74.34±5.57) μg/L and (61.64±4.29) μg/L, T_max (0.17±0) h and (0.25±0) h, AUC_0-t (637.38±30.04) μg·h·L^-1 and (172.41±31.66) μg·h·L^-1, and AUC_0-∞ (857.80±223.69) μg·h·L^-1 and (191.08±43.27) μg·h·L^-1, respectively. The intra-day, inter-day precision, and recovery rate met the criteria for content determination. Conclusion Compared with curcumin, CCPC can be absorbed more rapidly and eliminated more slowly.