Objective To study the wound-healing effect of combined gel preparation of different proportions of resveratrol and basic fibroblast growth factor(bFGF)on mustard gas-contaminated wounds, so as to provide evidence for optimizing the preparation of the combined drug gel. Methods A wound model was established by contaminating the back skin of rabbits with mustard gas (1.0 mg/cm²). The study was divided into treatment groups 1-11, positive treatment group, and negative contamination group, with 3 model animals in each group. The resveratrol (0.01, 0.02, and 0.04 g/mL) and bFGF (0.42, 2.08, and 4.17 μg/mL) were used to prepare combined drug gel by different proportions. The treatment groups 1-11 were treated externally with combined drug gels of corresponding proportions for 14 days. The positive treatment group and negative contamination group were treated with triamcinolone acetonide cream and gel without drugs, respectively. Changes of the wound appearance were observed and the healing extents were graded by predefined standard. Wound specimens were also collected for histopathological evaluation using H-E staining. The effects of different drug gel preparations on mustard gas-contaminated wounds were evaluated comprehensively. Results After external use of the combined drug gels for 3 d, the scores of skin injury including erythema, erosion and necrosis, histopathological inflammation, and necrosis of the contaminated wounds in treatment group-5 were significantly improved compared with those in the negative contamination group and other combined drug treatment groups(P<0.05), while showed no significant differences with the positive treatment group (P>0.05). Conclusion Combined drug gels in treatment group-5(0.02 g/mL resveratrol+2.08 μg/mL bFGF)can promote healing of the skin wound caused by mustard gas through inhibiting inflammatory response and cell necrosis of the wounded skin.