Objective:Through the 1:1 matched case-control study to investigate the relationship of thyroid-associated ophthalmopathy with type A personality and analyzed the risk factors of thyroid-associated ophthalmopathy.Methods:From 2013 October to 2014 February in Department of ophthalmopathy of Shanghai Changzheng Hospital outpatient and inpatient diagnosis of thyroid-associated ophthalmopathy and the age is 18 years old to 65 years old primary patients and healthy patients, a total of 201.The unity of "Psychology of personality" in 2012 August, the first edition of the first printed in line with China"s national conditions of the Type A Personality Questionnaire survey, Remove the Polygraph questions the L greater than or equal to 7 of the 81 questionnaires, collected 60 cases of thyroid-associated ophthalmopathy patients, and 60 healthy controls were enrolled a total of 120 cases.Two groups of patients by age, culture level (high school and above), the marriage 1:1 paired design, inclusion sex (female), family history of thyroid-associated ophthalmopathy, type A personality types as risk factors, using the mult-factor conditional Logistic regression analysis of case-control study.Result:the results of Multi factor Logistic regression analysis of thyroid associated ophthalmopathy and type A personality of showed that women, family history of Graves disease is a risk factor for thyroid associated ophthalmopathy, according with the literature,multivariate analysis showed that Type A personality OR value was 4.571 (90%CI:1.912-10.926), the P value is 0.0041, suggesting that the existence of the obvious relationship between the type A behaviour personality and thyroid associated ophthalmopathy.Combined with the results of single factor analysis, the TH (time hurry: time is pressing type) factors have obvious influence on thyroid associated ophthalmopathy, the value of OR was 1.126 (95%CI:1.029-1.233).Type A behaviour pattern was shown to be an independent risk factor for the development of TAO. Conclusion:the type A behaviour personality is conducive to thyroid associated ophthalmology prevention and rehabilitation.A personality, women and family history of thyroid associated ophthalmopathy were risk factors for thyroid associated ophthalmopathy, the type A personality especially TH (time urgency) is an important risk factor in the incidence of thyroid associated ophthalmopathy.People with type A personalities should be adjusted over time urgency, keeping a good mood is conducive to thyroid associated ophthalmology prevention and rehabilitation.