Hydrogen sulfide (H₂S) is the third endogenous gaseous mediator following nitric oxide and carbon monoxide. It has been demonstrated that H₂S plays important regulatory roles in modulating the physiological and pathophysiological processes of the nervous system, respiratory system, digestive system, and cardiovascular system. Recently, regulatory roles of H₂S in cardiovascular system are widely focused and seem to be complex. Here we sum up the roles of H₂S in mediating the cardiovascular regulation and illustrate its underlying mechanisms and perspectives.