Curcumin, a relatively low molecular weight polyphenol, is derived from the plant Curcuma longa, possessing anti-tumor, anti-inflammation, anti-virus, and anti-oxygenation effect. The anti-tumor effect of curcumin and its molecular mechanism are gradually recognized. The development and progression of tumor is multi-staged and drug intervention can be applied to any of these stages. We need drugs which can prevent and treat cancers safely and effectively. Natural medicine from food sources, such as curcumin, is suitable for all and for long-term use, especially in patients with low to moderate risk, owning to its less side effects, high safety and high patient compliance. However, the physical and chemical characters of curcumin make its usage undesirable, so to overcome these shortcomings has become a focus of research on curcumin. In this article we reviewed the new formulations of curcumin for anti-tumor usage.