Objective To assess the effects of applying pancreaticogastrostomy and pancreaticojejunostomy in central pancreatectomy on postoperative outcome and short-term complications. Methods The clinical data of 25 patients who received central pancreatectomy from May 2013 to May 2015 were retrospectively analyzed. The reconstruction methods were pancreaticogastrostomy or pancreaticojejunostomy, and the pancreatic duct were anastomosed with stomach or intestinal mucosa lips openings by magnetic induction line suture. Then the postoperative pancreatic fistula and hospital stay were compared between the two groups. Results The baseline data of two groups were comparable, and there were no significant differences in postoperative pancreatic fistula rates or hospital stay between the two groups. The 25 patients did not have anastomotic bleeding. Two cases with proximal pancreatic stump fistula were observed and were cured by adequate drainage, octreotide acetate injection, parenteral nutrition and so on. Conclusion Central pancreatectomy can better maintain the pancreas function. pancreaticogastrostomy and pancreaticojejunostomy are both safe.