Objective To evaluate the efficacy of percutaneous intervention closure of coronary artery fistula(CAF) and summarize our single-center experience. Methods We retrospectively analyzed the clinical data of 70 patients who successfully underwent transcatheter closure of CAF from August 2009 to August 2015 in our department. Results There were a total of 101 fistulas in the 70 patients (female 40%, average age[56.30±15.54] years, ranged from 15-83 years). And it was found that 8.91% of the CAFs were originated from the left main artery, 42.57% from the left anterior descending coronary artery, 14.85% from the left circumflex coronary artery, and 33.67% from the right coronary artery. The drainage sites included the pulmonary artery (78.22%), the right atrium(15.84%), the right ventricle(1.98%), and others (3.96%). The mean diameter of fistulas was (3.95±2.61) mm. All the 70 patients underwent transcatheter closure successfully, and the devices included coils (85.71%, mean number of coils were[2.55±1.76]), patent ductus arteriosus closures (7.14%), plug (2.86%), muscular ventricular septal defect occluders (2.86%) and covered stent (1.43%).The mean size of occluders was (13.33±4.32) mm. The patients received aspirin (3-5 mg/kg) every day for 6 months postoperatively. Follow-up ranged from 1 to 73 months (average[33.94±20.93]months), and no patient showed hemorrhage, hemolysis, thrombosis, chest pain or other complications. Conclusion Transcatheter closure of CAF is safe and efficient, with less trauma, and it is therefore worth popularizing in clinic.