Objective To observe the curative effect of soft silicone dressing combined with calcium alginate dressing for treatment of skin graft donor sites of burned patients. Methods A total of 80 burned patients were randomly divided into treatment group (n=39) and control group (n=41). In the treatment group the donor sites were covered with calcium alginate dressing (Sorbalgon) inside and soft silicone dressing (Mepilex) outside, and the donor sites in the control group were covered with chlorhexidine gauze inside and multilayer sterile gauze outside. The wound healing, pain improvement and scar formation were evaluated in the two groups. Results The wound healing rates at post-operative 7, 10 and 12 d in the treatment group were significantly higher than those in the control group (treatment group:[51.31±7.09]%,[78.77±8.80]% and[96.44±3.24]%; control group:[45.85±5.54]%,[73.63±7.73]% and[93.12±4.08]%; P<0.01). The wound healing time of the treatment group was significantly shorter than that of the control group ([10.95±1.41] d vs[11.93±1.44] d, P<0.01). Visual analogue scale (VAS) scores at post-operative 1, 3, 7 and 10 d in the treatment group were significantly lower than those in the control group (treatment group:5.36±1.21, 4.29±1.25, 4.00±0.46 and 1.00±0.45; control group:7.34±1.34, 5.89±1.39, 4.50±0.74 and 1.35±0.52; P<0.01). The Vancouver scar scale (VSS) scores at post-operative 1, 3, 6 and 12 month in the treatment group were also significantly lower than those in the control group (treatment group:3.82±1.47, 6.00±1.61, 3.77±2.28 and 2.59±1.39; control group:5.80±1.68, 7.80±1.65, 5.24±1.67 and 4.05±1.41; P<0.01). Conclusion Soft silicone dressing combined with calcium alginate dressing in treatment of the skin graft donor sites can greatly improve the wound healing rate, shorten the wound healing time, relieve pain in dressing change and improve the wound healing quality, and it may serve as an effective method for protecting the donor sites.