Objective To analyze and summarize the clinical characteristics and pregnancy outcomes of systemic lupus erythematosus (SLE) patients with pregnancy. Methods We retrospectively analyzed the clinical characteristics and pregnancy outcomes of 21 pregnant SLE patients in the Department of Obstetrics and Gynecology of Changhai Hospital of Navy Medical University (Second Military Medical University) from Jan. 2010 to Jun. 2017. Results Of 21 patients, 2 were diagnosed during pregnancy, and 9 out of 19 patients diagnosed before pregnancy were deteriorated and changed to active phase. Among the 21 patients, 13 cases (61.90%) received regular pregnancy examination, 17 cases (80.95%) gave birth, and 4 cases (19.05%) had induced labour. There were 6 cases (28.57%) having preeclampsia, 6 cases (28.57%) having premature birth, 5 cases (23.81%) having fetal intrauterine growth restriction, and 6 cases (28.57%) having fetal distress in uterus. Conclusion SLE patients have considerable risk of pregnancy, and pregnancy can induce SLE or aggravate the condition. SLE may cause serious maternal complications. Only at a stable condition can SLE patients start a pregnancy, and finish their pregnancy and puerperium under the joint monitoring of obstetricians and rheumatologists.