Objective To explore the risk factors and clinical features of intra-procedural rupture (IPR) in the interventional treatment of unruptured intracranial aneurysm (UIA), so as to reduce the incidence of IPR. Methods We retrospectively analyzed the clinical and imaging features of patients with UIA who received interventional treatment in Changhai Hospital, Second Military Medical University from Jan. 2010 to Feb. 2017. Univariate and multivariate analysis were performed to analyze the risk factors of IPR. Results A total of 1 232 patients with UIA were included in this study. IPR occurred in 11 patients (0.89%). Univariate analysis showed that cardiac comorbidities (P=0.025), anterior communicating artery aneurysm (P=0.009), irregular morphology (P=0.001), and the use of stents (P=0.016) were associated with IPR. Multivariate analysis showed that cardiac comorbidities (OR=6.919, P=0.008), irregular morphology (OR=9.758, P<0.001) and anterior communicating artery aneurysm (OR=4.648, P=0.024) were independent risk factors of IPR, while stents placement was a protective factor of IPR (OR=0.238, P=0.026). Conclusion Cardiac comorbidities, irregular morphology and anterior communicating artery aneurysm are independent risk factors of IPR in the interventional treatment of UIA. Stents and flow diverters are safe and feasible in treating UIAs, with low risk of IPR.