Objective To investigate the correlation between chronic hepatitis B virus (HBV) infection and coronary heart disease (CHD), so as to provide basis for decision-making in the prevention of CHD. Methods A total of 759 healthy volunteers without history of CHD, who received coronary computed tomography angiography (CTA) examination between Jan. 2013 and Jun. 2017 in our hospital, were included in the study. According to the levels of hepatitis B virus surface antigen (HBsAg), they were divided into HBV infection group (38 cases, all had chronic HBV infection) and control group (721 cases). Then we compared coronary artery lesions between the two groups, and analyzed the correlation between chronic HBV infection and CHD. Results Coronary CTA examination results showed that there was no significant difference in the prevalence of CHD between the two groups (21.05%[8/38] vs 28.02%[202/721], P>0.05). In addition, there were no significant differences in the number of coronary artery lesions, the type of plaque lesions or the distribution of diseased vessels with plaque between the HBV infection group and the control group (all P>0.05). Bivariate correlation analysis showed that there was no correlation between chronic HBV infection and CHD (r=0.034, P>0.05). Conclusion There is no clinical correlation between chronic HBV infection and CHD.