Objective To explore the individualized treatment strategies for ureterovesical junction (UVJ) stricture with stones. Methods The clinical data of 75 patients with UVJ stricture accompanied by stones in our department from Jan. 2010 to Jan. 2018 were retrospectively analyzed. Fifty cases were treated with internal urethrotomy and placed F5 double J tube, including 7 cases with dilation of UVJ through cystoscopy (2 cases were cut open 3-5 mm at UVJ), 41 cases with dilation plus lithotripsy through ureteroscopy (or holmium laser), and 2 cases accompanied by cysts at UVJ undergoing lithotripsy after transurethral ureterocele cystotomy. Twenty-five patients received conservative treatment, such as spasmolysis, diuresis and lithagogue after controlling renal colic. Results No stone or ureteral reflux was found in 7 cases with small stones treated with dilation of UVJ or the 2 cases accompanied by cysts at UVJ after one month of follow-up. No stone was found in 41 cases treated by dilation plus lithotripsy under ureteroscope after one month of follow-up. No stone was found in 25 cases with conservative treatment after 1-2 months of follow-up. Conclusion The stricture of UVJ should be regarded as a kind of disease and should be treated with internal urethrotomy or conservative methods according to the stone size and obstruction. For the patients with cyst at the UVJ, cutting cyst is appropriate.