Objective To explore the clinical efficacy of atorvastatin calcium combined with single-port double-tube irrigation and drainage in the treatment of chronic subdural hematoma. Methods The clinical prognosis and follow-up results of 42 patients with chronic subdural hematoma, who received treatment of atorvastatin calcium combined with single-hole double-tube irrigation and drainage in Department of Neurosurgery of our hospital from May 2016 to Apr. 2017, were retrospectively analyzed. There were 33 males and 9 females, aged 38-82 years with an average age of (70.0±5.8) years. Forty-two patients had headache and dizziness, and 36 patients had different severities of limb dysfunction. Results Of the 42 patients, 36 had unilateral chronic subdural hematoma and 6 had bilateral chronic subdural hematoma. The headache, dizziness and limb dysfunction were improved in all patients within 24 h after operation, and the symptoms completely disappeared after 1 month. Forty-one cases were completely cured, and cranial computed tomography (CT) examination showed that the hematoma completely disappeared at 3 months after operation in 22 cases and at 6 months after operation in 19 cases. One case (2.38%) with bilateral chronic subdural hematoma took warfarin orally due to atrial fibrillation. At 1 month after operation, the cranial CT examination showed a recurrence of chronic subdural hematoma, and the patient died of sudden cardiopulmonary arrest during follow-up. Conclusion Atorvastatin calcium combined with single-port double-tube irrigation and drainage is effective in the treatment of chronic subdural hematoma, and is worthy of popularization and application.