Objective To explore the application of high-speed dental handpiece and original luxator in the impacted wisdom tooth extraction. Methods Seventy patients with impacted wisdom teeth, who underwent impacted wisdom tooth extraction between Dec. 2016 and Dec. 2017, were selected. The patients were divided into control group (n=35) and minimally invasive group (n=35) according to the surgical options. The patients in the control group received conventional tooth extraction, and the patients in the minimally invasive group received tooth extraction using high-speed dental handpiece and original luxator. The surgical parameters (extraction integrity, mouth restriction, swelling and operation time), pain extent, complications and the quality of life after operation (psychological function, physiological function, physical pain, vitality) were compared between the two groups. Results The surgical parameters, including extraction integrity, mouth restriction, swelling and operation time, were significantly better in the minimally invasive group than those in the control group (all P<0.05). There was no significant difference in the visual simulation scale (VAS) score before extraction between the two groups (P>0.05). After extraction, the VAS score was significantly lower in the minimally invasive group than that in the control group (P<0.05). The incidence of complications in the minimally invasive group was 11.43% (4/35), which was significantly lower than that in the control group (34.29%[12/35], P<0.05). At 3 months after extraction, the scores of psychological function and the other quality of life scores were significantly higher in the minimally invasive group than those in the control group (all P<0.05). Conclusion Application of high-speed dental handpiece and original luxator in impacted wisdom tooth extraction can significantly improve the treatment efficacy and reduce complication incidence.