Cardiogenic stroke caused by atrial fibrillation is the most harmful type of stroke, causing great social burden. Prevention and treatment of cardiogenic stroke often require the joint decision by the cerebrovascular physicians and cardiologists. Within 14 d after onset, the early stage of stroke, is a high-risk period of stroke recurrence and also a high-risk period of cerebral hemorrhage. In this period, how to prevent stroke recurrence is an urgent problem to be solved. This paper summarizes the main ways of secondary prevention for cardiogenic stroke caused by atrial fibrillation and discusses the possibility of early secondary prevention.