支气管肺发育不良相关性肺动脉高压研究进展
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R722.6

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国家自然科学基金(81571467),上海交通大学医学院“紧缺专业硕士研究生临床研究能力提升计划”(JQ201803).


Advances in pulmonary hypertension associated with bronchopulmonary dysplasia
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Supported by National Natural Science Foundation of China (81571467) and “Program for Improving Clinical Research Ability of Urgently Needed Postgraduate Students” of Shanghai Jiao Tong University School of Medicine (JQ201803).

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    摘要:

    支气管肺发育不良(BPD)是早产儿常见的慢性呼吸系统疾病,严重影响早产儿的存活率及生存质量。肺动脉高压是包括BPD在内的早产儿慢性呼吸系统疾病的常见并发症。研究显示,并发肺动脉高压的BPD患儿的死亡率为14%~38%。尽管BPD相关性肺动脉高压的检查方法众多,但超声心动图检查仍然是主要评估手段。BPD相关性肺动脉高压的发病机制与预防措施仍未完全阐明,深入研究BPD相关性肺动脉高压有利于降低BPD死亡率和改善患儿预后。本文综述了BPD相关性肺动脉高压的高危因素、发病机制、诊断标准、筛查方法及防治措施。

    Abstract:

    Bronchopulmonary dysplasia (BPD) is a common premature chronic respiratory disease affecting the survival rate and the quality of life of premature infants. Pulmonary hypertension is a common complication of neonatal chronic respiratory diseases including BPD. Studies have shown that the mortality rate of BPD-associated pulmonary hypertension was 14%-38%. Although there are many methods to diagnose BPD-associated pulmonary hypertension, echocardiography is the most important one. The pathogenesis and preventive measures of BPD-associated pulmonary hypertension have not been fully elucidated. In-depth study on BPD-associated pulmonary hypertension is beneficial to reduce the mortality and improve the prognosis of children. This paper reviews the risk factors, pathogenesis, diagnosis criteria, screening methods and control measures of BPD-associated pulmonary hypertension.

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  • 收稿日期:2019-09-27
  • 最后修改日期:2019-11-26
  • 录用日期:2020-02-17
  • 在线发布日期: 2020-03-11
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