Ankylosing spondylitis (AS) is an immune-mediated chronic inflammatory disease characterized by involvement of sacroiliac and spinal joints. The main pathological features of AS are enthesitis and new bone formation-caused joint fusion, but its pathogenesis is still unclear. Wnt signaling pathway exerts an important effect on the normal bone homeostasis, especially on the formation of osteoblasts, and may contribute to the pathogenesis of AS. Studies have shown that chronic inflammation and genetic regulation participate in the new bone formation of AS through Wnt signaling pathway. This review sums up the effect of Wnt/β-catenin signaling pathway on bone metabolism of AS in recent years.