Objective To explore the pathogeneic characteristics and ideas of ultrasonic diagnosis of type 2 multiple endocrine neoplasm (MEN-2), so as to improve the clinical diagnosis rate. Methods The clinical data of 2 patients with pathologically confirmed MEN-2 in Changzheng Hospital of Naval Medical University (Second Military Medical University) were retrospectively analyzed. The pathogenic characteristics of 2 patients were summarized. The process of ultrasound diagnosis was discussed, and the ideas of ultrasound diagnosis was summarized. Results Patient 1 presented with hypertension. Abdominal ultrasonography showed multiple pheochromocytomas in the bilateral adrenal glands, which attracted attention because of bilateral involvement. Further examination of other endocrine glands revealed that the right upper and middle thyroid junction had an occupation, and there was no abnormality in the pancreas. Ultrasound finally diagnosed medullary thyroid carcinoma. Patient 2 had recurrent urinary calculi for many years. Considering its symptoms might be caused by hyperparathyroidism, we performed ultrasonography and found hyperplasia of parathyroid gland and medullary thyroid cancer. Therefore, we further examined several endocrine organs such as pancreas and adrenal gland, and finally found pheochromocytoma of adrenal gland. Based on the different clinical symptoms of the 2 patients, we made accurate diagnoses through ultrasound examination of endocrine glands associated with multiple lesions combined with pathological results. Conclusion MEN-2 has a variety of clinical manifestations and is difficult to diagnose. It is helpful for early diagnosis of MEN-2, a multi-organ involvement disease, by mastering its pathogenic characteristics, clinical characteristics and ultrasound diagnosis ideas.