Objective To evaluate the clinical effect of conjoint fascial sheath (CFS) suspension in treatment of severe blepharoptosis. Methods A total of 43 patients (68 eyes) with severe blepharoptosis were treated with CFS suspension in Changzheng Hospital of Naval Medical University (Second Military Medical University) from Jul. 2016 to Sep. 2018. The clinical data of the 68 eyes with severe blepharoptosis were retrospectively analyzed. The correction effect of this method was evaluated by the margin reflex distance (MRD1) and its improvement, the radian of eyelid margin, the shaping of double eyelid line and complications. The patients were followed up for 3-12 months. Results Blepharoptosis was effectively corrected after CFS suspension. Three months after operation, MRD1 was improved by (3.84±0.55) mm and blepharoptosis was significantly improved versus before operation (P<0.01). According to MRD1 improvement, 66 eyes (97.06%, 66/68) were satisfactory and 2 eyes (2.94%, 6/68) were improved, with the upper eyelid margin being symmetrical and the radian being natural. The upper eyelid regained part of the movement one week after operation; and 3 months after operation, all patients could completely close the eyes. There were few postoperative complications:2 cases had exposed keratitis in the early stage, which was cured after drug treatment; and there were no other complications such as eyelid ectropion, trichiasis, eye movement disorder, or diplopia. Conclusion CFS suspension is effective for correction of severe blepharoptosis, with the advantage of good appearance, natural activity, minor trauma, easy repetition, less complications, and high satisfaction rate with curative effect, and it is worth popularizing in clinic.