Objective To summarize the surgical experience on extraperitoneal suprapubic robot-assisted laparoscopic simple prostatectomy (RASP) in the treatment of benign prostatic hyperplasia (BPH), and to discuss the efficacy and safety of this procedure. Methods A retrospective analysis was conducted on the clinical data of 15 patients with BPH undergoing extraperitoneal suprapubic RASP from Apr. 2015 to Nov. 2018. The operation time, estimated blood loss, postoperative bladder irrigation time, postoperative drainage time, postoperative catheterization time, postoperative hospital stay and complications were recorded. The postoperative international prostate symptom score (IPSS), quality of life (QoL), post-voiding residual volume (PVR) and maximal flow rate (Q_max) were compared with those before operation. Results The operation was successfully completed in all the 15 cases. The operation time (console time) averaged (92.0±28.3) min, estimated blood loss averaged (105.0±42.5) mL, and no patient needed blood transfusion. The postoperative bladder irrigation averaged (2.2±0.5) days, postoperative drainage averaged (1.8±0.6) days, postoperative catheterization averaged (5.7±1.2) days, and postoperative hospital stay averaged (4.1±1.3) days. Clavien-Dindo gradeⅠcomplications occurred in three cases, and gradeⅡcomplications occurred in one case. After 3 months of follow-up, the values of IPSS, QoL, PVR and Q_max were significantly improved in the patients (all P<0.01). Conclusion Extraperitoneal suprapubic RASP is a safe and effective surgical procedure for the treatment of BPH.