Motion sickness refers to vestibular and autonomic nervous responses such as dizziness, nausea and vomiting caused by stimulation of real or virtual environment, and its pathogenesis remains to be fully elucidated. Due to the multiple symptoms and great individual variability, there is no single effective treatment for motion sickness, and acclimatization training is still one of the most effective strategies. The innovative development of traditional Chinese medicine and its combined application with Western medical equipment such as electrical nerve stimulation, have shown great potential for the prevention and treatment of motion sickness. This article reviews the pathogenesis, diagnosis and treatment of motion sickness, hoping to provide guidance for exploring new effective treatment programs of motion sickness.