As the outbreak of coronavirus disease 2019 (COVID-19) continues, hospitals in Wuhan have invested great efforts to combat the epidemic. The risk of nosocomial infection and cross infection should not be ignored, and the treatment of non-COVID-19 patients was challenged. According to the characteristics of COVID-19, our hospital has established a transitional ward, enforced the screening and exclusion procedures of COVID-19. We also scientifically formulated and smoothly operated various programs and procedures for the treatment of emergency and critical patients, so that non-COVID-19 patients can be treated in time, ensuring medical safety and nursing quality, also effectively avoiding the spread of COVID-19 in non-isolated areas of the hospital, which has played a very important role at the outbreak stage of the epidemic.