Angiogenesis plays an important role in the development and metastasis of tumors, diabetic retinopathy, arthritis and other diseases. Angiogenesis involves a variety of cytokines and signaling pathways. Nanomaterials are a new type of material with many unique physicochemical properties. It is reported that nanomaterials have anti-angiogenesis effects. This review introduces the angiogenesis and its molecular mechanism, and focuses on the research progress of the antiangiogenesis effects of gold, silver, zinc oxide, carbon and other nanomaterials, providing more drug options for clinical antiangiogenesis therapy.