Objective To analyze the progress, research focus and future trends of Tuina therapy for knee osteoarthritis in the past 10 years by using CiteSpace knowledge mapping software. Methods The related literature on Tuina therapy for knee osteoarthritis from Jan. 1, 2010 to May 11, 2020 were retrieved from CNKI database. After Refworks format conversion, CiteSpace 5.6 R3 software was used to construct the knowledge map. The co-occurrence analysis of authors, institutions and keywords were conducted, and time-sharing hotspot views of the relevant literature on Tuina treatment for knee osteoarthritis were drawn. Results A total of 426 articles were identified, with the number of papers on a rise annually. There were 302 authors, and the main collaborators were GONG Li, FANG Min, YAN Jun-tao and SUN Wu-quan from Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine. The research institutions were relatively scattered, and the most published institutions was also Yueyang Hospital of Integrated Traditional Chinese and Western Medicine (19 articles); the cooperation among institutions in the same region or within the same system was much closer, while less cooperation was found between institutions in different regions. There were 92 key words, with 13 having frequency >10 and centrality ≥ 0.1. Four prominent words were detected, including "Tuina manipulation", "osteoarthritis", "review" and "curative effect", among which "osteoarthritis" (2011-2013) and "curative effect" (2018-2020) as heated research topics lasted 3 years. Conclusion The authors and the institutions should strengthen cooperation with each other and make efforts to increase the depth and innovation of the research, so as to promote the research on Tuina therapy for knee osteoarthritis.