Human bone tissue is always in the processes of continuous wearing and reconstruction with a certain stability. However, when subjected to external forces such as extrusion, impact or surgery, it will lead to bone fracture, nonunion and other serious consequences, and the steady state of the whole-body bone system will be broken. In order to restore the normal anatomical structure and function, the body promotes osteogenic metabolism and repairs bone trauma by inducing osteogenesis and inhibiting apoptosis. Hippo pathway is one of the effective ways of intracellular and extracellular signal transmission, regulating the processes of cell proliferation and differentiation, and affecting the osteogenic metabolism. The purpose of this review is to point out the direction of exploring the related potential mechanism.