Objective To translate the coronary artery disease education questionnaire short version (CADE-Q SV) into Chinese and to assess its reliability and validity in patients with coronary artery disease (CAD) in Shanghai. Methods CADE-Q SV was translated and culture-adapted by improved Brislin backward translation model. Sixteen CAD patients were randomly selected from Xinhua Hospital, Shanghai Jiao Tong University School of Medicine for cognitive interview, and the Chinese version of CADE-Q SV was finally formed. The clarity and content validity of the questionnaire were evaluated by an expert panel composing of 2 cardiovascular physicians, 2 cardiovascular nurses, 2 physiotherapists and 2 dieticians. A total of 263 CAD patients were randomly selected from Xinhua Hospital, Shanghai Jiao Tong University School of Medicine to finish the online questionnaire. Among them, 47 patients finished the questionnaire again after 1-week interval, and the test-retest reliability and internal consistency reliability were tested. Data from the rest 216 patients were extracted for construct validity and discrimination validity analyses. Results The instruction clarity score of the Chinese version of CADE-Q SV was 9.9±0.4, and the average clarity score of the 20 items was 9.8±0.4; the item-content validity index (I-CVI) of the 20 items ranged from 0.88 to 1.00, and the scale-content validity index/average (S-CVI/Ave) was 0.98. The test-retest reliability intraclass correlation coefficient (ICC) for each item ranged from 0.30-0.88, for the total score of the scale was 0.82, and the Cronbach's α coefficient of internal consistency was 0.77. The result of confirmatory factor analysis showed that χ²/df was 1.66, root mean square error of approximation (RMSEA) was 0.05, and adjusted goodness of fit index (AGFI) was 0.82. There were significant differences in the questionnaire scores among the participants with different education levels (P<0.01). Conclusion The Chinese version of CADE-Q SV showed promising reliability and validity in patients with CAD in Shanghai. It can be used to evaluate the level of CAD knowledge in this population, helping medical staff to develop personalized education programs and evaluate the effect of education in clinical cardiac rehabilitation.