Objective To analyze the efficacy and safety of middle meningeal artery (MMA) embolization in the treatment of chronic subdural hematoma. Methods Nineteen consecutive patients with chronic subdural hematoma, who received MMA embolization in the Stroke Center of Changhai Hospital of Naval Medical University (Second Military Medical University) from Mar. 2018 to May 2020, were included retrospectively. The recurrence and progress of hematoma, technical success rate and incidence of procedure-related complications were analyzed 3 months after MMA embolization. Results Of the 19 patients, 17 were males and 2 females, aged 51-85 years, with an average age of (67.4±7.9) years. There were 21 hematomas in the 19 patients. Of them, 6 hematomas underwent simple MMA embolization and 15 underwent MMA embolization combined with burr-hole drainage (7 burr-hole drainage after MMA embolization and 8 before embolization). Procedures for all the 21 hematomas were successfully performed, and 17 of them were treated with Onyx glue and 4 with Glubran glue. No patients had technique-related complications. All the 19 patients received clinical and imaging follow-up, and the clinical symptoms were all improved, and none of them had recurrence or progress of hematoma 3 months after embolization. Conclusion MMA embolization is a new treatment for chronic subdural hematoma with high safety and low recurrence rate. However, this result needs to be further verified by large-scale randomized controlled trials.