At present,oxidative stress plays an increasingly prominent role in the pathogenesis of osteoporosis.It has been found that the accumulation of high levels of reactive oxygen species and related oxidation products can break the balance of bone metabolism and lead to osteoporosis.In recent years,researches of Chinese materia medica and its chemical constituents in preventing and treating osteoporosis by alleviating oxidative stress are growing,and some achievements have been obtained.In this paper,the pathogenesis of osteoporosis mediated by oxidative stress was briefly reviewed by referring to relevant literatures,the researches and applications of Chinese materia medica and its antioxidant chemicals,such as flavonoids,polyphenols and saponins on osteoporosis were also introduced,and it may provide reference for the clinical application and research and development of new drug.