In recent years, several studies have demonstrated that the left atrial appendage is closely related to the induction and maintenance of atrial fibrillation, and the left atrial appendage electrical isolation (LAAEI) has been confirmed to effectively improve the success rate of atrial fibrillation ablation and reduce the recurrence of atrial fibrillation. Currently, LAAEI is mainly achieved through radiofrequency or cryoballoon ablation, surgical intervention, LARIAT ligation, etc. However, it is necessary to promote the understanding of its complications, especially the postoperative thrombus events and stroke. This paper reviews the anatomical characteristics of left atrial appendage, as well as the clinical treatment progress and related complications of LAAEI.