Atrial fibrillation (AF) is one of the most common arrhythmias in clinical scenario and its symptoms can lead to a decline in the quality of life and increase the risk of ischemic stroke and heart failure in patients.Catheter ablation can effectively relieve the symptoms of AF patients,but there is no enough evidence that it reduces the incidence of stroke.Left atrial appendage closure is an effective method for the prevention of stroke caused by AF.The one-stop operation of catheter ablation combined with left atrial appendage closure is suitable for nonvalvular AF patients with high risk of stroke and bleeding.This article reviews the safety,effectiveness and influencing factors of the efficacy of catheter ablation combined with left atrial appendage closure for clinical reference.