Liposomal bupivacaine exparel is currently the only local anesthetic sustained-release preparation on the market. It has been approved for single-dose infiltration and interscalene brachial plexus block in adults. With the development of regional anesthesia, off-label use of exparel is gradually increasing. This article reviews the application of exparel in trunk nerve block, peripheral nerve block and intraspinal anesthesia in recent years, evaluates its safety and effectiveness, and pays attention to researches about the application of exparel in special population.