Objective To explore the feasibility, safety and effectiveness of ultrasound-guided microwave ablation for benign parotid gland tumors. Methods From Jul. 2013 to Jun. 2021, ultrasound-guided core needle biopsy was performed on patients with clinically diagnosed parotid mass and suspected parotid tumor diagnosed by ultrasound. Benign parotid tumors based on the biopsy histopathology were treated by using ultrasound-guided microwave ablation. The ablated area of parotid gland was evaluated by dynamic ultrasound imaging, and complications related to needle biopsy and ablative treatment were followed up. Results A total of 13 parotid tumors underwent core needle biopsy as designed during the past 8 years. Twelve benign tumors were treated with ultrasound-guided microwave ablation, including 6 adenolymphomas, 4 polymorphic adenomas, 1 dermoid cyst, and 1 nodular lymphoid hyperplasia. The age of the 12 patients were 10-79 years old (median 60.5 years old), and the maximum diameter of the tumor was 17.8-49.0 mm (median 26.15 mm). Microwave ablation was performed all at one time with a duration of 70-598 s (median 155 s) in all patients. By the deadline of this paper, 10 patients had recovered, and the time required for complete absorption in the ablation area was 8-37 months (median 23.5 months). No residual tumor was observed in the ablation area and no neoplasm was observed in the rest parotid gland. There were no serious complications after ablation. Conclusion Ultrasound-guided microwave ablation can provide accurate and minimally invasive treatment opportunities for benign parotid tumors with mild complications.