Abstract:Chikungunya fever (CHIKF) is an acute infectious disease caused by Chikungunya virus (CHIKV) and characterized by fever, rash and chronic joint pain. CHIKF has become one of the important global public health issues, with about 1 million cases in more than 100 countries and regions around the world each year. Vaccination is the most important, effective and economical means to prevent infectious diseases. However, due to insufficient funding for basic researches and clinical trials, as well as the continuous adaptive mutations of the virus, the development process of vaccine against CHIKV is generally slow. No licensed vaccine is yet available to prevent CHIKF, but there have been several vaccine candidates undergoing clinical trials. This review briefly summarizes the research progress on CHIKV vaccines in recent years.