Objective To analyze the correlation between chest parameter response mapping (PRM) and forced expiratory volume in one second (FEV₁) in community population based on low dose-computed tomography (CT) screening. Methods A total of 2 428 subjects who underwent low-dose CT screening in our hospital from Aug. 2018 to Jul. 2021 were retrospectively enrolled. According to the emphysema index (EI), they were divided into non-emphysema group (EI<6%, n=1 992) and emphysema group (EI ≥ 6%, n=436), and further divided into non-emphysema+non-smoking group (n=1 033), non-emphysema+smoking group (n=307), emphysema+non-smoking group (n=203), and emphysema+smoking group (n=165) according to their smoking history. The PRM parameters of the subjects were obtained through thin-layer CT post-processing, including whole lung volume, emphysema volume, functional small airway disease volume, normal lung tissue volume, and the percentage of the latter 3 indicators in whole lung volume; total right lung volume, emphysema volume, functional small airway disease volume, normal lung tissue volume, and the percentage of the latter 3 indicators in total right lung volume; and total left lung volume, emphysema volume, functional small airway disease volume, normal lung tissue volume and the latter 3 indicators accounted for the percentage of the total left lung volume, respectively. The differences of the age, gender, body mass index (BMI), smoking history, FEV₁ and PRM parameters between the groups with or without emphysema and the correlation between the PRM parameters and FEV₁ between the 4 groups were analyzed. Results The age of subjects, the proportion of male patients and FEV₁ in the emphysema group were higher than those in the non-emphysema group, while the BMI was lower than those in the non-emphysema group (all P<0.05). The comparison of PRM parameters between the emphysema group and the non-emphysema group showed that the percentages of normal lung tissue volume in the volume of the whole lung, right and left lung in the emphysema group were smaller than those in the non-emphysema group (all P<0.001), while the other indexes were larger than those in the non-emphysema group (all P<0.001). In the emphysema+smoking group, the normal lung tissue volumes of the whole lung, right and left lung and their percentages in the total volume were weakly to moderately positively correlated with FEV₁ (r_s=0.258-0.482, all P<0.001). The volumes of emphysema and functional small airway disease of the whole lung, right and left lung as well as the percentages of the above 2 indicators in the total volume of the whole lung, right lung and left lung, respectively, were weakly to moderately negatively correlated with FEV₁ (r_s=-0.368——0.189, all P<0.05). Conclusion PRM parameters are different in population with or without emphysema. In population with emphysema and smoking, PRM parameters have varying degrees of correlation with FEV₁. PRM is expected to become an early warning marker for screening high-risk groups with airflow limitation.