Objective To summarize the experience of hemostatic gauze packing in the treatment of uncontrollable massive hemorrhage during hepatectomy. Methods The clinical data of 120 patients who underwent complicated hepatectomy with hemostatic gauze packing in The Third Affiliated Hospital of Naval Medical University (Second Military Medical University) from Nov. 2011 to May 2021 were retrospectively analyzed, and the in-hospital mortality was calculated. The patients were divided into non-death group and death group according to the occurrence of in-hospital death. The differences of blood routine, coagulation function, liver function and other indexes were compared between the 2 groups before and after operation. Multivariate logistic regression model was used to analyze the influencing factors of in-hospital death. Results Only 10 patients died in hospital, with a mortality of 8.33%. Patients were divided into non-death group (n=110) and death group (n=10). The albumin, red blood cells, hemoglobin, platelets, and γ-glutamyl transpeptidase of the patients in the death group were lower than those in the non-death group on the 1^st day after operation, and the creatinine, international normalized ratio (INR), prothrombin time (PT) and activated partial thromboplastin time (APTT) were higher than those in the non-death group on the 1^st day after operation (all P<0.05). Multivariate logistic regression analysis showed that the patient's age, PT and APTT on the 1^st day after operation were independent influencing factors for in-hospital death. Conclusion Hemostatic gauze packing has a significant effect for the treatment of massive hepatic hemorrhage during hepatectomy, and the operation technique is simple. It is a practical and effective method of hemostasis and is worthy of clinical promotion.