Objective To compare the clinical diagnostic value of 2 different cardiac contrast-enhanced ultrasound (CEUS) techniques (ultrasonic microbubble angiography and rapid turbulence angiography) in determining the position of the central venous catheter tip. Methods A total of 107 adult critical patients with central venous catheterization who were admitted to Department of Critical Care Medicine, Peking University People's Hospital from Jul. 2020 to Mar. 2022 were enrolled. The position of the central venous catheter tip was determined by ultrasonic microbubble angiography and rapid turbulence angiography. The accuracy of the 2 CEUS techniques in determining the position of the central venous catheter tip was analyzed using the results of bedside chest X-ray (CXR) as the standard. Results The median time required to determine the position of the central venous catheter tip by ultrasonic microbubble angiography and rapid turbulence angiography was 6 (5-7) min and 5 (4-6) min, respectively, which were shorter than that by bedside CXR (70[57-90] min) (both P<0.01). With bedside CXR as the gold standard for the determination of catheter position, the ultrasonic microbubble angiography and rapid turbulence angiography showed consistent results, with a sensitivity of 100.0% and a specificity of 81.2% for both methods. Conclusion Compared with bedside CXR, the ultrasonic microbubble angiography and rapid turbulence angiography can determine the position of the central venous catheter quickly and accurately. In addition, rapid turbulence angiography without injection of contrast agent is more worthy of further clinical application.