Objective To explore the effects of a domestic wearable transcutaneous acupoint electrical stimulation bracelet on preventing seasickness. Methods A total of 76 medical personnel who were on their first naval mission from Jan. 2020 to Jul. 2022 were selected. After all participants boarded the ship, they filled out the motion sickness susceptibility questionnaire-adult version (MSSQ-Adt), and the MSSQ-R3-Adt index was calculated. Participants were allocated to experimental group and control group using variable block randomization, with 38 participants in each group. The participants in the experimental group wore transcutaneous acupoint electrical stimulation bracelets 0.5 h before sailing and the bracelets were switched on to stimulate the Neiguan acupoint. The participants in the control group wore bracelets but did not receive electrical stimulation. After 72 h of sailing, all participants filled out an improved seasickness symptom questionnaire, and the severity of seasickness was rated. Results The incidence of seasickness in the experimental group was significantly lower than that in the control group (31.6% ［12/38］ vs 65.8% ［25/38］, χ²＝7.584, P＝0.006). The risk of seasickness in the control group was 2.0 times higher than that in the experimental group (relative risk＝2.0, 95% confidence interval 1.3-3.3). The incidence of seasickness in female participants was significantly higher than that in male participants (80.0% ［24/30］ vs 28.3% ［13/46］, χ²＝17.441, P＜0.05). The participants with seasickness had significantly higher MSSQ-R3-Adt index than those without seasickness (12.3 ［7.0, 28.0］ vs 4.7 ［0.0, 11.0］, U＝330.0, P＜0.05). Conclusion The domestic wearable transcutaneous acupoint electrical stimulation bracelet can effectively reduce the incidence of seasickness.