Tachyarrhythmia is an important clinical feature of septic shock. Poorly controlled persistent tachycardia is closely related to poor prognosis. The pathogenesis of septic shock-related tachyarrhythmia is complex, and drug therapy is still the main choice to control septic shock-related arrhythmia. Diversity of drug choices exists, so the selection and use of antiarrhythmic drugs need to be further studied. This article mainly reviews the research progress in the pathogenesis and treatment of septic shock-related tachyarrhythmia.