Abstract:Objective To summarize the imaging characteristics of hepatic epithelioid hemangioendothelioma (EHE) and analyze the misdiagnosed cases. Methods The clinical and imaging data of 11 patients with hepatic EHE confirmed by surgical or puncture pathology from Feb. 2015 to Dec. 2021 were retrospectively analyzed. Results All 11 patients underwent magnetic resonance imaging (MRI) and 2 cases underwent computed tomography (CT). Ten cases showed multiple liver lesions and 1 case showed a single solid lesion. A total of 78 lesions were detected in all 11 patients. Seven cases were misdiagnosed before surgery, of which 4 were misdiagnosed as liver metastases, 1 as intrahepatic cholangiocarcinoma, 1 as hemangioma, and 1 as benign lesion. CT plain scan showed uneven low-density lesions. The lesions presented slightly hypointensity on T1 weighted imaging and slightly hyperintensity on T2 weighted imaging. After enhancement, the lesions showed annular continuous enhancement (9 cases) or cloud flocculent gradual enhancement (2 cases). Nine cases had Halo sign on T2 weighted imaging, 5 cases showed multiple lesions fusing with each other, 7 cases had liver capsule retraction, 7 cases showed lollipop sign in portal vein phase of MRI enhanced scan, and 6 cases showed vascular penetration sign. Conclusion Hepatic EHE is more likely to be misdiagnosed; however, EHE has certain imaging characteristics. Knowing the imaging features of hepatic EHE can help improve the diagnostic accuracy.