Objective To observe the clinical effect of Jianpi Lishi Tongluo decoction combined with Yongquan moxibustion in the treatment of chronic lower limb venous edema (CLLVE) with damp pathogen and blood stasis syndrome. Methods Seventy CLLVE patients with damp pathogen and blood stasis syndrome were randomly divided into 2 groups, with 35 cases in each group. The control group received Yongquan moxibustion treatment, while the experimental group received Jianpi Lishi Tongluo decoction in addition to Yongquan moxibustion. Both groups were treated for 4 weeks. The total effective rate of the 2 groups was calculated, and the traditional Chinese medicine (TCM) symptom scores, symptoms and signs scores, limb circumferences, serum inflammatory factor levels and safety of the 2 groups were compared before and after treatment. Results A total of 34 patients were included in the experimental group, and the total effective rate was 91.17% (31/34). A total of 33 patients were included in the control group, and the total effective rate was 69.70% (23/33). The total effective rate of the experimental group was significantly higher than that of the control group (P＝0.026). After treatment, both groups showed decreased TCM syndrome scores, symptom and sign scores of the affected limb, circumferences of the affected limb 15 cm below the lower edge of patella and 2 cm above the upper edge of tibial medial condyle, and levels of inflammatory factors (interleukin-6 and tumor necrosis factor-α) (all P＜0.05). Moreover, the above indexes in the experimental group were significantly lower than those in the control group except for the circumference of the limb 2 cm above the upper edge of tibial medial condyle (all P＜0.05). During the treatment, no abnormalities were observed in the liver or kidney functions for either group, and there were no serious adverse reactions. Conclusion Jianpi Lishi Tongluo decoction combined with Yongquan moxibustion can significantly improve symptoms and signs of affected limbs in CLLVE patients with damp pathogen and blood stasis syndrome and reduce systemic inflammation response.