Objective To investigate the status of learning burnout, mental health and coping styles of adolescents with learning difficulties, and analyze its influencing factors, so as to provide guidance for preventing and correcting adolescents’ learning difficulties. Methods A questionnaire survey was conducted among 102 adolescents with learning difficulties. The general information was collected with a self-designed questionnaire. The learning burnout, mental health and coping styles were investigated by the adolescent learning burnout scale, symptom checklist 90 (SCL-90), and middle school students’ coping style scale. The scores of learning burnout, mental health and coping styles among adolescents with learning difficulties with different demographic characteristics were compared, and linear regression analysis was used to explore the influencing factors of learning burnout, mental health and coping styles. Results The total score of adolescent learning burnout scale of 102 adolescents with learning difficulties was 55.71±9.86, and the average score of SCL-90 was 2.60±0.80. In coping styles, the score of problem solving was 19.11±6.08, seeking help was 19.94±10.22, enduring was 8.86±2.06, avoiding was 14.31±4.15, venting was 10.35±3.06, and fantasizing was 6.75±3.22. Females were more likely to suffer from learning burnout and mental health problems, while males were more likely to use problem solving coping style (all P＜0.05). Individuals with poor family economic status were more likely to use venting coping style, while those with better family economic status were more likely to use fantasizing coping style (both P＜0.05). Individuals with good family relationship had less learning burnout, while those with poor family relationship were more inclined to use venting coping style (both P＜0.05). Individuals from divorced families had more serious mental health problems, while those from intact families were more inclined to use problem solving coping style (both P＜0.05). Learning burnout and mental health problems were more serious in individuals who experienced major changes during their growth period (both P＜0.05). Individuals with shorter nighttime sleep duration had more serious learning burnout and mental health problems (both P＜0.05). Those who had not experienced lockdown or isolation during the epidemic of coronavirus disease 2019 were more likely to use problem solving coping style (P＜0.05). Linear regression analysis showed that gender, family relationship and nighttime sleep duration were the influencing factors of learning burnout (all P＜0.05). Nighttime sleep duration, major changes during the growth period and gender were the influencing factors of mental health (all P＜0.05). Family situation was the influencing factor of problem solving in coping styles, and family relationship was the influencing factor of venting in coping styles (both P＜0.05). Conclusion Adolescents with learning difficulties have obvious learning burnout and poor mental health. Factors such as gender, family relationship, and sleep duration should be emphasized in the future.