Motion sickness refers to a multi-system physiological syndrome caused by abnormal acceleration and motion vision scene immersion. It occurs commonly in transportation, military operations, space exploration and other fields. This article reviews recent advances in mechanism, prediction and assessment as well as control measures for motion sickness, and discusses possible research direction of motion sickness in the future. The biological basis for motion sickness sensory conflict theory has been expanded; genomic sequencing and artificial intelligence techniques have been used as novel tools for motion sickness prediction and evaluation. Acclimatization training, anti-motion sickness medication and non-drug symptom control measures used in combination is the key for motion sickness prevention and treatment.