Objective To explore the objective indicators of tongue and pulse manifestations in patients with endometriosis diseases by collecting the data of tongue and pulse manifestations of patients with endometriosis diseases by digital tongue and pulse diagnostic instrument. Methods The endometriosis disease group included 72 patients with endometriosis diseases who were treated in Department of Gynecology (Professor ZHANG Tingting), Yueyang Hospital of Integrated Traditional Chinese and Western Medicine from Jun. 1, 2021 to Sep. 15, 2022. The normal group included 35 healthy adult women recruited by the Physical Examination Center of Shuguang Hospital, Shanghai University of Traditional Chinese Medicine. Results In terms of age, there was no significant difference between the endometriotic disease group and normal group (P＞0.05). In terms of tongue color, the values of zhiCon, zhiASM, zhiENT, zhiMEAN, zhiClrB, zhiClrI, zhiClrLa, zhiClrCb, and zhiClrLb in the endometriosis disease group were significantly different from those in the normal group (all P＜0.05), while there were no significant differences in the values of zhiClrR, zhiClrG, zhiClrS, zhiClrL, zhiClrY, or zhiClrCr between the 2 groups (all P＞0.05). In terms of tongue coating color, the values of taiClrR, taiClrB, taiClrI, taiClrS, taiClrLa, taiClrLb, taiClrCr, and taiClrCb in the endometriosis disease group were significantly different from those in the normal group (all P＜0.05), while there were no significant differences in the values of taiClrG, taiClrL, or taiClrY (all P＞0.05). In terms of texture and thickness of tongue coating, there were no significant differences in the values of perAll, perPart, taiCon, taiASM, taiENT, or taiMEAN between the 2 groups (all P＞0.05). In terms of pulse manifestation, the values of h3, h4, h5, t4, h3/h1, and h4/h1 in the endometriosis disease group were significantly different from those in the normal group (all P＜0.05), while there were no significant differences in the values of h1, t, t1, or t5 (all P＞0.05). Conclusion There are significant differences in tongue and pulse indicators between patients with endometriosis diseases and healthy individuals. It can provide objective indicators for further research on the pathogenesis changes and clinical differentiation of endometriosis diseases.