Peripheral pulmonary lesions (PPL), including peripheral pulmonary nodules, are common lung problems. As the increase of patients with lung nodules, the demand for tissue sampling also increases. Safe and accurate biopsy techniques are very important for patients to identify benign and malignant lesions. Electronic bronchoscopy is one of the biopsy techniques for the diagnosis of PPL in recent decades. Various guiding techniques, such as radial probe endobronchial ultrasound and virtual navigation bronchoscope, have been proved to improve the performance of conventional bronchoscopy. This paper aims to provide an review of the available data on advanced bronchoscopic techniques and explore their application in diagnosing PPL.