Many genomic features of lymphohematopoietic tissue tumors have been recognized by molecular pathological testing and high-throughput sequencing technology. The gene detection technology and its progress are of great significance for the diagnosis and treatment of lymphoma. This paper introduces new technologies for the pathological diagnosis and research of lymphoma, including whole genome sequencing, circulating tumor DNA analysis, single cell analysis and epigenetic research, etc. The latest progress in the genetic characteristics, prognostic stratification and treatment prospects of common lymphoma based on the new WHO classification of lymphohematopoietic tissue tumors will help to guide the pathological diagnosis and clinical treatment of lymphoma.