Atrial fibrillation is one of the most common arrhythmias; its high incidence rate and high disability rate lead to heavy social and economic burdens. Most atrial fibrillation originates from pulmonary veins, so pulmonary vein isolation is the mainstay of catheter ablation for the treatment of atrial fibrillation. Cryoballoon ablation has the advantages of reversible injury, short operation time, and better surgical experience for patients. At present, it has been widely used in clinical practice and has become the first-line treatment scheme for atrial fibrillation. However, compared with radiofrequency ablation, cryoballoon ablation carries a relatively higher risk of causing phrenic nerve injury, particularly during the process of cryoablation targeting the right pulmonary vein. Therefore, this article aims to discuss the strategies for preventing phrenic nerve injury during cryoballoon ablation for atrial fibrillation, such as the temperature monitoring during cryoablation and the strategies of balloon operation (i.e. balloon deflation, proximal occlusion, phrenic nerve pacing), so as to summarize the experience and effectively prevent complications.