Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly, and its main pathological manifestations include senile plaques formed by β-amyloid deposition and neuronal fibrillar nodules formed by hyperphosphorylation of tau proteins. Lysosome is an important organelle in eukaryotic cells, containing a variety of hydrolytic enzymes that can break down proteins and other biomolecules. It is closely related to intracellular transport and autophagy, and is important for maintaining cellular homeostasis. This review summarizes the interaction between lysosomal dysfunction and the development and progression of AD and the potential therapeutic mechanisms in treating AD by regulating and restoring the functions of lysosomes. Lysosomal dysfunction can lead to neurodegenerative diseases such as AD. Modulation of lysosomal function is a promising treatment strategy for AD. It is expected that more drugs and therapeutic regimens based on this mechanism can be used in the clinical treatment for AD patients in the future.