Objective To investigate the prevalence and the risk factors of heart disease (HD) in adults aged ≥80 years old in China based on the data from the 8th round of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Methods A total of 7 675 adults aged ≥80 years old were enrolled from the 8^th round of CLHLS dataset. Chi-square tests were employed to examine associations between cardiovascular disease and demographic characteristics, socioeconomic status, social support, lifestyle factors, and health indicators. Logistic regression models were developed to analyze significant predictors of heart disease in the elderly. Results The prevalence of heart disease was 16% (n＝1 228) in 7 675 elderly people. Aged 90-99 years old (odds ratio ［OR］ ＝0.816), ≥100 years old (OR＝0.641), female (OR＝0.833), and low body mass index (BMI) (＜18.5 kg/m², OR＝0.778) were the protective factors for cardiovascular disease in the elderly; and high BMI (24.0 to 27.9 kg/m², OR＝1.209), rural residence (OR＝2.384), health examination (OR＝1.164), dysfunction of daily living activities (OR＝1.401), hypertension (OR＝2.143), diabetes mellitus (OR＝1.719), and history of cerebrovascular accident (OR＝2.080) were risk factors. Conclusion Male, overweight, rural residence, health examination, dysfunction of daily living activities, hypertension, diabetes mellitus, and a history of cerebrovascular accident are the risk factors for heart disease in the elderly.